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Multi-purpose functionality for the structural elaboration of the piperazine-2,5-dione motif

Chai, Christina; Elix, John; Huleatt, Paul


Mild methods for controlled C- and N-alkylation of 3-benzyloxycarbonylpiperazine-2,5-diones are reported. The benzyloxylcarbonyl substituent can also serve as latent functionality for N-acyliminium ion formation and subsequent trapping enables installation of new carbon and/or heteroatom substituents.

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Tetrahedron Letters
DOI: 10.1016/S0040-4039(02)02571-6


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