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Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Hanna, Amy; Lam, Alex; Thekkedam, Chris; Gallant, Esther; Beard, Nicole; Dulhunty, Angela

Description

Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca2+]. Basal leak from the sarcoplasmic reticulum is required for normal Ca2+ handling, but

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/76293
Source: Journal of Cell Science
DOI: 10.1242/jcs.156760
Access Rights: Open Access

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