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Cardiac ryanodine receptor activation by a high Ca2+ store load is reversed in a reducing cytoplasmic redox environment

Hanna, Amy; Lam, Alex; Thekkedam, Chris; Gallant, Esther; Beard, Nicole; Dulhunty, Angela


Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca2+]. Basal leak from the sarcoplasmic reticulum is required for normal Ca2+ handling, but

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Cell Science
DOI: 10.1242/jcs.156760
Access Rights: Open Access


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01_Hanna_Cardiac_ryanodine_receptor_2014.pdf1.52 MBAdobe PDF
02_Hanna_Cardiac_ryanodine_receptor_2014.pdf1.52 MBAdobe PDF

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