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Cohesin Rad21 Mediates Loss of Heterozygosity and Is Upregulated via Wnt Promoting Transcriptional Dysregulation in Gastrointestinal Tumors

Xu, Huiling; Yan, Yuqian; Deb, Siddhartha; Rangasamy, Danny; Germann, Markus; Malaterre, Jordane; Eder, Noreen; Ward, Robyn; Hawkins, Nicholas; Tothill, Richard; Chen, Long; Mortensen, Neil; Fox, Stephen; McKay, Michael; Ramsay, Robert

Description

Loss of heterozygosity (LOH) of the adenomatous polyposis coli (. APC) gene triggers a series of molecular events leading to intestinal adenomagenesis. Haploinsufficiency of the cohesin Rad21 influences multiple initiating events in colorectal cancer (CRC). We identify Rad21 as a gatekeeper of LOH and a β-catenin target gene and provide evidence that Wnt pathway activation drives RAD21 expression in human CRC. Genome-wide analyses identified Rad21 as a key transcriptional regulator of critical...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/76221
Source: Cell Reports
DOI: 10.1016/j.celrep.2014.10.059

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