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Clinical outcomes and genome-wide association for a brain methylation site in an antidepressant pharmacogenetics study in Mexican Americans

Wong, Ma-Li; Dong, Chuanhui; Flores, Deborah H; Ehrhart-Bornstein, Monika; Bornstein, Stefan; Arcos-Burgos, Mauricio (Oscar); Licinio, Julio

Description

Objective: The authors compared the effectiveness of fluoxetine and desipramine treatment in a prospective double-blind pharmacogenetics study in first-generation Mexican Americans and examined the role of whole-exome functional gene variations in the patients' antidepressant response.Method: A total of 232 Mexican Americans who met DSM-IV criteria for major depressive disorder were randomly assigned to receive 8 weeks of double-blind treatment with desipramine (50-200 mg/day) or fluoxetine...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/76180
Source: American Journal of Psychiatry
DOI: 10.1176/appi.ajp.2014.12091165

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