Export of virulence proteins by malaria-infected erythrocytes involves remodeling of host actin cytoskeleton
Rug, Melanie; Cyrklaff, Marek; Mikkonen, Antti; Lemgruber, Leandro; Kuelzer, Simone; Sanchez, Cecilia P.; Thompson, Jennifer; Hanssen, Eric; O'Neill, Matthew T.; Langer, Christine; Lanzer, Michael; Frischknecht, Friedrich; Maier, Alex; Cowman, Alan F.
Following invasion of human red blood cells (RBCs) by the malaria parasite, Plasmodium falciparum, a remarkable process of remodeling occurs in the host cell mediated by trafficking of several hundred effector proteins to the RBC compartment. The exported virulence protein, P falciparum erythrocyte membrane protein 1 (PfEMP1), is responsible for cytoadherence of infected cells to host endothelial receptors. Maurer clefts are organelles essential for protein trafficking, sorting, and assembly of...[Show more]
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