Moriya, Mie; Taniguchi, Shunichiro; Wu, Peter; Liepinsh, Edvards; Otting, Gottfried; Sagara, Junji
Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an adaptor protein composed of two homophilic protein-protein interaction domains, a PYRIN domain (PYD) and a caspase recruitment domain. PYD-dependent oligomerization of ASC is thought to play a crucial role in formation of a molecular platform, the inflammasome, which activates caspase-1. When expressed in cells, the PYD of ASC was shown to form cytoplasmic filaments through self-association. Over 70...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.