Integron-associated mobile gene cassettes code for folded proteins: the structure of Bal32a, a new member of the adaptable α+β barrel family
Robinson, Andrew; Wu, Peter; Harrop, Stephen; Schaeffer, Patrick; Dosztanyi, Zsuzsanna; Gillings, Michael; Holmes, Andrew; Nevalainen, K M Helena; Stokes, Harold W; Dixon, Nicholas; Curmi, Paul; Mabbutt, Bridget; Otting, Gottfried
The wide-ranging physiology and large genetic variability observed for prokaryotes is largely attributed, not to the prokaryotic genome itself, but rather to mechanisms of lateral gene transfer. Cassette PCR has been used to sample the integron/gene cassette metagenome from different natural environments without laboratory cultivation of the host organism, and without prior knowledge of any target protein sequence. Since over 90% of cassette genes are unrelated to any sequence in the current...[Show more]
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