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Total synthesis of sordaricin

Mander, Lewis; Thomson, Regan

Description

(Chemical Equation Presented) An enantioconvergent total synthesis of sordaricin (3), the diterpene aglycon of an important class of antifungal compounds, is described. Two approaches were explored, the first of which utilized a possible biogenetic intramolecular [4 + 2] cycloaddition to form the complete carbon skeleton of the target molecule as a single regioisomer 30. A second approach employed a tandem cycloreversion/ intramolecular [4 + 2] cycloaddition process to afford not only the...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/76080
Source: Journal of Organic Chemistry
DOI: 10.1021/jo048199b

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