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A complex mechanism determines polarity of DNA replication fork arrest by the replication terminator complex of Bacillus subtilis

Duggin, Iain; Matthews, Jacqueline; Dixon, Nicholas; Wake, R. Gerry; Mackay, Joel Peter


Two dimers of the replication terminator protein (RTP) of Bacillus subtilis bind to a chromosomal DNA terminator site to effect polar replication fork arrest. Cooperative binding of the dimers to overlapping half-sites within the terminator is essential for arrest. It was suggested previously that polarity of fork arrest is the result of the RTP dimer at the blocking (proximal) side within the complex binding very tightly and the permissive-side RTP dimer binding relatively weakly. In order to...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Biological Chemistry
DOI: 10.1074/jbc.M414187200


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