A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumour angiogenesis and invasion in a mouse model of multistage cancer
Heparan sulfate proteoglycans are integral components of the extracellular matrix that surrounds all mammalian cells. In addition to providing structural integrity, they act as a storage depot for a variety of heparan sulfate (HS)-binding proteins, including growth factors and chemokines. Heparanase is a matrix-degrading enzyme that cleaves heparan sulfate side chains from the core proteoglycans, thus liberating such HS-binding proteins, as well as potentially contributing to extracellular...[Show more]
|Collections||ANU Research Publications|
|01_Joyce_A_functional_heparan_sulfate_2005.pdf||679.21 kB||Adobe PDF||Request a copy|
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.