Skip navigation
Skip navigation

A functional heparan sulfate mimetic implicates both heparanase and heparan sulfate in tumour angiogenesis and invasion in a mouse model of multistage cancer

Joyce, Johanna A; Freeman, Craig; Meyer-Morse, Nicole; Hanahan, Douglas; Parish, Christopher


Heparan sulfate proteoglycans are integral components of the extracellular matrix that surrounds all mammalian cells. In addition to providing structural integrity, they act as a storage depot for a variety of heparan sulfate (HS)-binding proteins, including growth factors and chemokines. Heparanase is a matrix-degrading enzyme that cleaves heparan sulfate side chains from the core proteoglycans, thus liberating such HS-binding proteins, as well as potentially contributing to extracellular...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Oncogene
DOI: 10.1038/sj.onc.1208602


File Description SizeFormat Image
01_Joyce_A_functional_heparan_sulfate_2005.pdf679.21 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator