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The structure of the USP/RXR of Xenos pecki indicates that Strepsiptera are not closely related to Diptera

Hayward, David; Trueman, John; Bastiani, M J; Ball, Eldon

Description

The receptor for the insect molting hormone, ecdysone, is a heterodimer consisting of the Ecdysone Receptor and Ultraspiracle (USP) proteins. The ligand binding domain sequences of arthropod USPs divide into two distinct groups. One group consists of sequences from members of the holometabolous Lepidoptera and Diptera, while the other arthropod sequences group with vertebrate retinoid-X-receptors (RXRs). We therefore wondered whether USP/RXR structure could be used to clarify the contentious...[Show more]

dc.contributor.authorHayward, David
dc.contributor.authorTrueman, John
dc.contributor.authorBastiani, M J
dc.contributor.authorBall, Eldon
dc.date.accessioned2015-12-13T22:34:06Z
dc.identifier.issn0949-944X
dc.identifier.urihttp://hdl.handle.net/1885/75987
dc.description.abstractThe receptor for the insect molting hormone, ecdysone, is a heterodimer consisting of the Ecdysone Receptor and Ultraspiracle (USP) proteins. The ligand binding domain sequences of arthropod USPs divide into two distinct groups. One group consists of sequences from members of the holometabolous Lepidoptera and Diptera, while the other arthropod sequences group with vertebrate retinoid-X-receptors (RXRs). We therefore wondered whether USP/RXR structure could be used to clarify the contentious phylogenetic position of the order Strepsiptera, which has proposed affinities with either Diptera or Coleoptera. We have cloned and sequenced the USP/RXR from the strepsipteran Xenos pecki. Phylogenetic analyses are not consistent with a close affinity between Strepsiptera and Diptera.
dc.publisherSpringer
dc.sourceDevelopment Genes and Evolution
dc.subjectKeywords: cell nucleus receptor; ecdysone; ecdysone receptor; retinoid X receptor; ultraspiracle protein; unclassified drug; amino acid sequence; arthropod; article; Coleoptera; controlled study; fly; insect; Lepidoptera; ligand binding; molecular cloning; nonhuman Ecdysone receptor; RXR; Strepsiptera; Ultraspiracle; Xenos
dc.titleThe structure of the USP/RXR of Xenos pecki indicates that Strepsiptera are not closely related to Diptera
dc.typeJournal article
local.description.notesImported from ARIES
local.description.refereedYes
local.identifier.citationvolume215
dc.date.issued2005
local.identifier.absfor060301 - Animal Systematics and Taxonomy
local.identifier.ariespublicationMigratedxPub4910
local.type.statusPublished Version
local.contributor.affiliationHayward, David, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationTrueman, John, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBastiani, M J, University of Utah
local.contributor.affiliationBall, Eldon, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.startpage213
local.bibliographicCitation.lastpage219
local.identifier.doi10.1007/s00427-004-0461-x
dc.date.updated2015-12-11T09:17:59Z
local.identifier.scopusID2-s2.0-17544379731
CollectionsANU Research Publications

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