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Functional polymorphism of human glutathione transferase A2

Tetlow, Natasha; Board, Philip

Description

Objectives: Single nucleotide polymorphisms that cause amino acid substitutions in enzymes involved in the metabolism of xenobiotics can potentially have a significant effect on the efficacy and safety of therapeutic drugs. Methods: We have utilized a bioinformatic approach to identify new polymorphisms in the glutathione transferase super family. Results and conclusions: In this report we describe a P110S polymorphism in GSTA2 that occurs at a low frequency in Africans, Chinese and Europeans....[Show more]

CollectionsANU Research Publications
Date published: 2004
Type: Journal article
URI: http://hdl.handle.net/1885/75808
Source: Pharmacogenetics and Genomics
DOI: 10.1097/00008571-200402000-00005

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