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Egr-1 mRNA expression is a marker for the direction of Mammalian ocular growth

Ashby, Regan; Zeng, Guang; Leotta, Amelia J; Tse, Dennis; McFadden, Sally A


METHODS. To induce accelerated growth and myopia, guinea pigs wore a -5 diopter (D) lens over one eye from 4 to 11 days of age. To induce inhibited growth, the lens was removed after 7 days of -5 D lens wear, and the eye allowed to recover from myopia for 3 days. Ocular parameters and Egr-1 mRNA levels were subsequently assessed, and compared to untreated fellow eyes and eyes from untreated littermates. Possible circadian changes in Egr-1 mRNA levels were also determined in 18 additional...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Investigative Ophthalmology and Visual Science
DOI: 10.1167/iovs.13-11708
Access Rights: Open Access


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