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Characterization of the chloroquine resistance transporter homologue in Toxoplasma gondii

Warring, Sally D; Dou, Zhicheng; Carruthers, Vern B.; McFadden, Geoffrey I; van Dooren, Giel

Description

Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) protein confer resistance to the antima-larial drug chloroquine. PfCRT localizes to the parasite digestive vacuole, the site of chloroquine action, where it mediates resistance by transporting chloroquine out of the digestive vacuole. PfCRT belongs to a family of transporter proteins called the chlo-roquine resistance transporter family. CRT family proteins are found throughout the Apicomplexa, in some protists,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/75709
Source: Eukaryotic Cell
DOI: 10.1128/EC.00027-14

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