Warring, Sally D; Dou, Zhicheng; Carruthers, Vern B.; McFadden, Geoffrey I; van Dooren, Giel
Mutations in the Plasmodium falciparum chloroquine resistance transporter (PfCRT) protein confer resistance to the antima-larial drug chloroquine. PfCRT localizes to the parasite digestive vacuole, the site of chloroquine action, where it mediates resistance by transporting chloroquine out of the digestive vacuole. PfCRT belongs to a family of transporter proteins called the chlo-roquine resistance transporter family. CRT family proteins are found throughout the Apicomplexa, in some protists,...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.