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Quantitative trait locus mapping methods for diversity outbred mice

Gatti, Daniel M.; Svenson, Karen L; Shabalin, Andrey; Wu, Long-Yang; Valder, William; Simecek, Petr; Goodwin, Neal; Cheng, Riyan; Pomp, Daniel; Palmer, Abraham; Chesler, Elissa J; Churchill, Gary A

Description

Genetic mapping studies in the mouse and other model organisms are used to search for genes underlying complex phenotypes. Traditional genetic mapping studies that employ single-generation crosses have poor mapping resolution and limit discovery to loci that are polymorphic between the two parental strains. Multiparent outbreeding populations address these shortcomings by increasing the density of recombination events and introducing allelic variants from multiple founder strains. However,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/75614
Source: G3: Genes, Genomes, Genetics
DOI: 10.1534/g3.114.013748

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