Gatti, Daniel M.; Svenson, Karen L; Shabalin, Andrey; Wu, Long-Yang; Valder, William; Simecek, Petr; Goodwin, Neal; Cheng, Riyan; Pomp, Daniel; Palmer, Abraham; Chesler, Elissa J; Churchill, Gary A
Genetic mapping studies in the mouse and other model organisms are used to search for genes underlying complex phenotypes. Traditional genetic mapping studies that employ single-generation crosses have poor mapping resolution and limit discovery to loci that are polymorphic between the two parental strains. Multiparent outbreeding populations address these shortcomings by increasing the density of recombination events and introducing allelic variants from multiple founder strains. However,...[Show more]
Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.