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Different HIV pox viral vector-based vaccines and adjuvants can induce unique antigen presenting cells that modulate CD8 T cell avidity

Trivedi, Shubhanshi; Jackson, Ronald; Ranasinghe, Charani


The lung-derived dendritic cell (LDC) recruitment following intranasal (i.n.) vaccination of different poxviral vector-based vaccines/adjuvants were evaluated to decipher how these factors influenced CD8+ T cell avidity. Compared to the standard i.n. recombinant fowlpox virus (FPV)-HIV vaccination, the FPV-HIV IL-13Rα2 or IL-4Rα antagonist adjuvanted vaccines that induced higher avidity CD8+ T cells, also recruited significantly elevated MHCII+ CD11c+ CD11b+ CD103- CD64- MAR-1- conventional DC...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2014.09.004


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