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Two-year changes in refractive error and related biometric factors in an adult Chinese population

He, Mingguang; Kong, Xiangbin; Chen, Qianyun; Zeng, Y; Huang, Yuanzhou; Zhang, Jian; Morgan, Ian; Meltzer, Mirjam E.; Jin, Ling; Congdon, Nathan

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IMPORTANCE This article provides, to our knowledge, the first longitudinal population-based data on refractive error (RE) in Chinese persons. OBJECTIVE To study cohort effects and changes associated with aging in REs among Chinese adults. DESIGN, SETTING, AND PARTICIPANTS A 2-year, longitudinal population-based cohort study was conducted in southern China. Participants, identified using cluster random sampling, included residents of Yuexiu District, Guangzhou, China, aged 35 years or older who...[Show more]

dc.contributor.authorHe, Mingguang
dc.contributor.authorKong, Xiangbin
dc.contributor.authorChen, Qianyun
dc.contributor.authorZeng, Y
dc.contributor.authorHuang, Yuanzhou
dc.contributor.authorZhang, Jian
dc.contributor.authorMorgan, Ian
dc.contributor.authorMeltzer, Mirjam E.
dc.contributor.authorJin, Ling
dc.contributor.authorCongdon, Nathan
dc.date.accessioned2015-12-13T22:32:16Z
dc.identifier.issn2168-6165
dc.identifier.urihttp://hdl.handle.net/1885/75489
dc.description.abstractIMPORTANCE This article provides, to our knowledge, the first longitudinal population-based data on refractive error (RE) in Chinese persons. OBJECTIVE To study cohort effects and changes associated with aging in REs among Chinese adults. DESIGN, SETTING, AND PARTICIPANTS A 2-year, longitudinal population-based cohort study was conducted in southern China. Participants, identified using cluster random sampling, included residents of Yuexiu District, Guangzhou, China, aged 35 years or older who had undergone no previous eye surgery. METHODS Participants underwent noncycloplegic automated refraction and keratometry in December 2008 and December 2010; in a random 50% sample of the participants, anterior segment ocular coherence tomography measurement of lens thickness, as well as measurement of axial length and anterior chamber depth by partial coherence laser interferometry, were performed. MAIN OUTCOMES AND MEASURES Two-year change in spherical equivalent refraction (RE), lens thickness, axial length, and anterior chamber depth in the right eye. RESULTS A total of 745 individuals underwent biometric testing in both 2008 and 2010 (2008 mean [SD] age, 52.2 [11.5] years; 53.7%women). Mean RE showed a 2-year hyperopic shift from -0.44 (2.21) to -0.31 (2.26) diopters (D) (difference, +0.13; 95%CI, 0.11 to 0.16). A consistent 2-year hyperopic shift of 0.09 to 0.22 D was observed among participants aged 35 to 64 years when stratifying by decade, suggesting that a substantial change in RE with aging may occur during this 30-year period. Cross-sectionally, RE increased only in the cohort younger than 50 years (0.11 D/y; 95%CI, 0.06 to 0.16). In the cross-sectional data, axial length decreased at -0.06 mm/y (95%CI, -0.09 to -0.04), although the 2-year change in axial length was positive and thus could not explain the cross-sectional difference. These latter results suggest a cohort effect, with greatermyopia developing among younger persons. CONCLUSIONS AND RELEVANCE This first Chinese population-based longitudinal study of RE provides evidence for both important longitudinal aging changes and cohort effects, most notably greatermyopia prevalence among younger persons.
dc.publisherAmerican Medical Association
dc.sourceJAMA Ophthalmology
dc.titleTwo-year changes in refractive error and related biometric factors in an adult Chinese population
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume132
dc.date.issued2014
local.identifier.absfor111301 - Ophthalmology
local.identifier.ariespublicationU3488905xPUB4643
local.type.statusPublished Version
local.contributor.affiliationHe, Mingguang, Sun Yat-sen University
local.contributor.affiliationKong, Xiangbin, Sun Yat-Sen University
local.contributor.affiliationChen, Qianyun, Sun Yat-Sen University
local.contributor.affiliationZeng, Y, Sun Yat Sen University
local.contributor.affiliationHuang, Yuanzhou, Sun Yat-Sen University
local.contributor.affiliationZhang, Jian, Sun Yat-Sen University
local.contributor.affiliationMorgan, Ian, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMeltzer, Mirjam E., Sun Yat-Sen University
local.contributor.affiliationJin, Ling, Sun Yat-Sen University
local.contributor.affiliationCongdon, Nathan, Zhongshan Ophthalmic Center
local.description.embargo2037-12-31
local.bibliographicCitation.issue8
local.bibliographicCitation.startpage978
local.bibliographicCitation.lastpage984
local.identifier.doi10.1001/jamaophthalmol.2014.1011
local.identifier.absseo920107 - Hearing, Vision, Speech and Their Disorders
dc.date.updated2015-12-11T09:05:56Z
local.identifier.scopusID2-s2.0-84907352728
CollectionsANU Research Publications

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