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Biophysical implications of lipid bilayer rheometry for mechanosensitive channels

Bavi, Navid; Nakayama, Yoshitaka; Bavi, Omid; Cox, Charles D; Qin, Qing Hua; Martinac, Boris


The lipid bilayer plays a crucial role in gating of mechanosensitive (MS) channels. Hence it is imperative to elucidate the rheological properties of lipid membranes. Herein we introduce a framework to characterize the mechanical properties of lipid bilayers by combining micropipette aspiration (MA) with theoretical modeling. Our results reveal that excised liposome patch fluorometry is superior to traditional cell-attached MA for measuring the intrinsic mechanical properties of lipid bilayers....[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.1409011111
Access Rights: Open Access


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