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Dissociation of T helper type 2 cytokine-dependent airway lesions from signal transducer and activator of transcription 6 signalling in experimental chronic asthma

Foster, Paul S; Webb, Dianne; Yang, Ming; Herbert, John; Kumar, Rakesh K


Background: Type 2 T helper lymphocytes (Th2 cells) and their cytokine products are important in the pathogenesis of asthma. Objective: To examine the contribution of the signal transducer and activator of transcription (STAT) 6 pathway, involved in Th2 cytokine signalling, to the development of lesions of chronic asthma. Methods: BALB/c mice sensitized to ovalbumin were chronically challenged by inhalational of low mass concentrations of antigen for 6 weeks. Airway lesions in wild-type mice...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Clinical and Experimental Allergy
DOI: 10.1046/j.1365-2222.2003.01647.x


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