Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series
Stoll, Vincent; Stewart, Kent; Maring, Clarence; Muchmore, Steven; Giranda, Vincent; Gu, Yu-gui; Wang, Gary; Chen, Yuanwei; Sun, Minghua; Zhao, Chen; Kennedy, April L; Madigan, Darold; Xu, Yibo; Saldivar, Ayda; Kati, Warren; Laver, W. Graeme; Sowin, Thomas; Sham, Hing; Greer, Jonathan; Kempf, Dale
Combinatorial and structure-based medicinal chemistry strategies were used together to advance a lead compound with an activity of Ki = 58 μM via a potency enhancement of < 70 000-fold to an analogue with an activity of Ki = 0.8 nM against influenza neur
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