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Influenza Neuraminidase Inhibitors: Structure-Based Design of a Novel Inhibitor Series

Stoll, Vincent; Stewart, Kent; Maring, Clarence; Muchmore, Steven; Giranda, Vincent; Gu, Yu-gui; Wang, Gary; Chen, Yuanwei; Sun, Minghua; Zhao, Chen; Kennedy, April L; Madigan, Darold; Xu, Yibo; Saldivar, Ayda; Kati, Warren; Laver, W. Graeme; Sowin, Thomas; Sham, Hing; Greer, Jonathan; Kempf, Dale

Description

Combinatorial and structure-based medicinal chemistry strategies were used together to advance a lead compound with an activity of Ki = 58 μM via a potency enhancement of < 70 000-fold to an analogue with an activity of Ki = 0.8 nM against influenza neur

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
URI: http://hdl.handle.net/1885/75368
Source: Biochemistry
DOI: 10.1021/bi0205449

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