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Synthesis of quaternised 2-aminopyrimido[4,5- d ]pyrimidin-4(3 H )-ones and their biological activity with dihydrofolate reductase

Gebauer, Markus; McKinlay, Carolyn; Gready, Jill


In a program to design and develop mechanism-based compounds active as substrates and inhibitors of dihydrofolate reductase (DHFR), we report the synthesis and physical properties of the 6-methyl- (7), 8-methyl- (8a), and 8-ethyl- (8b) derivatives of the

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: European Journal of Medicinal Chemistry
DOI: 10.1016/S0223-5234(03)00140-5


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