Synthesis of quaternised 2-aminopyrimido[4,5- d ]pyrimidin-4(3 H )-ones and their biological activity with dihydrofolate reductase
In a program to design and develop mechanism-based compounds active as substrates and inhibitors of dihydrofolate reductase (DHFR), we report the synthesis and physical properties of the 6-methyl- (7), 8-methyl- (8a), and 8-ethyl- (8b) derivatives of the
|Collections||ANU Research Publications|
|Source:||European Journal of Medicinal Chemistry|
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