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Functionality of the 5- and intergenic IRES elements of cricket paralysis virus in a range of insect cell lines, and its relationship with viral activities

Masoumi, Amir; Hanzlik, Terry; Christian, Peter D


Cricket paralysis virus (Dicistroviridae: Cripavirus) (CrPV) naturally has a wide range of insect hosts which is reflected in its ability to infect several cultured insect cell lines. The expression of viral gene products is controlled by two kinds of internal ribosome entry site (IRES) elements, 5′ and intergenic (IG). Using seven cultured cell lines we tested the functionality of both IRES elements by transfection with bi-cistronic RNA constructs. In six of the seven cell lines, expression...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Virus Research
DOI: 10.1016/S0168-1702(03)00139-4


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