Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: The case for pantothenamides
Malaria kills more than half a million people each year. There is no vaccine, and recent reports suggest that resistance is developing to the antimalarial regimes currently recommended by the World Health Organization. New drugs are therefore needed to ensure malaria treatment options continue to be available. The intra-erythrocytic stage of the malaria parasite's life cycle is dependent on an extracellular supply of pantothenate (vitamin B5), the precursor of CoA (coenzyme A). It has been...[Show more]
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|Source:||Biochemical Society Transactions|
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