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Discovery and refinement of muscle weight QTLs in B6 X D2 advanced intercross mice

Carbonetto, P; Cheng, Riyan; Gyekis, J P; Parker, C C; Blizard, David A; Palmer, A A; Lionikas, Arimantas

Description

The genes underlying variation in skeletal muscle mass are poorly understood. Although many quantitative trait loci (QTLs) have been mapped in crosses of mouse strains, the limited resolution inherent in these conventional studies has made it difficult to reliably pinpoint the causal genetic variants. The accumulated recombination events in an advanced intercross line (AIL), in which mice from two inbred strains are mated at random for several generations, can improve mapping resolution. We...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/75078
Source: Physiological Genomics
DOI: 10.1152/physiolgenomics.00055.2014

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