Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model
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Davies, Paul; Vincent, Mark; Lineweaver, Charles
Description
In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target-the-weakness strategy. Our most...[Show more]
Collections | ANU Research Publications |
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Date published: | 2014 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/75061 |
Source: | Bioessays |
DOI: | 10.1002/bies.201400070 |
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01_Lineweaver_Targeting_cancer's_weaknesses_2014.pdf | 397.24 kB | Adobe PDF | Request a copy |
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