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Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model

Davies, Paul; Vincent, Mark; Lineweaver, Charles

Description

In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target-the-weakness strategy. Our most...[Show more]

dc.contributor.authorDavies, Paul
dc.contributor.authorVincent, Mark
dc.contributor.authorLineweaver, Charles
dc.date.accessioned2015-12-13T22:30:55Z
dc.identifier.issn0265-9247
dc.identifier.urihttp://hdl.handle.net/1885/75061
dc.description.abstractIn the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target-the-weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in immunosuppressed tumor environments is an irreversible weakness of cancer that can be exploited by creating a challenge that only the presence of adaptive immunity can meet. This leaves tumor cells more vulnerable than healthy tissue to pathogenic attack. Such a target-the-weakness therapeutic strategy has broad applications, and contrasts with current therapies that target the main strength of cancer: cell proliferation.
dc.publisherThe Company of Biologists Ltd
dc.sourceBioessays
dc.titleTargeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume36
dc.date.issued2014
local.identifier.absfor060000 - BIOLOGICAL SCIENCES
local.identifier.ariespublicationU3488905xPUB4446
local.type.statusPublished Version
local.contributor.affiliationLineweaver, Charles, College of Physical and Mathematical Sciences, ANU
local.contributor.affiliationDavies, Paul, Arizona State University
local.contributor.affiliationVincent, Mark , University of Western Ontario
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage827
local.bibliographicCitation.lastpage835
local.identifier.doi10.1002/bies.201400070
dc.date.updated2015-12-11T08:57:55Z
local.identifier.scopusID2-s2.0-84905918016
local.identifier.thomsonID000340497000005
CollectionsANU Research Publications

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