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Targeting cancer's weaknesses (not its strengths): Therapeutic strategies suggested by the atavistic model

Lineweaver, Charles; Davies, Paul; Vincent, Mark

Description

In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target-the-weakness strategy. Our most...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
URI: http://hdl.handle.net/1885/75061
Source: Bioessays
DOI: 10.1002/bies.201400070

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