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Voltage- and site-dependent control of the somatic impact of dendritic IPSPs

Williams, Stephen; Stuart, Gregory J


Inhibitory interneurons target specific subcellular compartments of cortical pyramidal neurons, where location-specific interactions of IPSPs with voltage-activated ion channels are likely to influence the inhibitory control of neuronal output. To investigate this, we simulated IPSPs as a conductance source at sites across the somato-apical dendritic axis (up to 750 μm) of neocortical layer 5 pyramidal neurons. Analysis revealed that the electrotonic architecture of cortical pyramidal neurons...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Neuroscience


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