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Studies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis

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Tjhin, Erick; Staines, Henry M; Van Schalkwyk, Donelly; Krishna, Sanjeev; Saliba, Kevin

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To characterise plasmodial glycolysis, we generated two transgenic Plasmodium falciparum lines, one expressing P. falciparum hexokinase (PfHK) tagged with GFP (3D7-PfHKGFP) and another overexpressing native PfHK (3D7-PfHK+). Contrary to previous reports,

dc.contributor.authorTjhin, Erick
dc.contributor.authorStaines, Henry M
dc.contributor.authorVan Schalkwyk, Donelly
dc.contributor.authorKrishna, Sanjeev
dc.contributor.authorSaliba, Kevin
dc.date.accessioned2015-12-13T22:30:26Z
dc.identifier.issn0014-5793
dc.identifier.urihttp://hdl.handle.net/1885/74838
dc.description.abstractTo characterise plasmodial glycolysis, we generated two transgenic Plasmodium falciparum lines, one expressing P. falciparum hexokinase (PfHK) tagged with GFP (3D7-PfHKGFP) and another overexpressing native PfHK (3D7-PfHK+). Contrary to previous reports,
dc.publisherElsevier
dc.sourceFEBS Letters
dc.subjectKeywords: deoxyglucose; glucose; glucose transporter; hexokinase; article; cellular distribution; controlled study; cytosol; enzyme activity; glucose transport; glycolysis; nonhuman; Plasmodium falciparum; priority journal; transgenic organism; Glucose; Hexokinase; Glucose; Hexokinase; Hexose transport; Malaria; Plasmodium
dc.titleStudies with the Plasmodium falciparum hexokinase reveal that PfHT limits the rate of glucose entry into glycolysis
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume587
dc.date.issued2013
local.identifier.absfor060100 - BIOCHEMISTRY AND CELL BIOLOGY
local.identifier.ariespublicationf5625xPUB4330
local.type.statusPublished Version
local.contributor.affiliationTjhin, Erick, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationStaines, Henry M, University of London
local.contributor.affiliationVan Schalkwyk, Donelly, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationKrishna, Sanjeev, St. George's Hospital Medical School
local.contributor.affiliationSaliba, Kevin, College of Medicine, Biology and Environment, ANU
local.description.embargo2037-12-31
local.bibliographicCitation.issue19
local.bibliographicCitation.startpage3182
local.bibliographicCitation.lastpage3187
local.identifier.doi10.1016/j.febslet.2013.07.052
dc.date.updated2016-02-24T09:23:58Z
local.identifier.scopusID2-s2.0-84884291474
local.identifier.thomsonID000324472200004
CollectionsANU Research Publications

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