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Variance-mean analysis: a simple and reliable approach for investigating synaptic transmission and modulation

Clements, John D


The mechanisms underlying synaptic plasticity can be investigated by analyzing synaptic amplitude fluctuations before and after a synaptic modulation. However, many older fluctuation analysis techniques rely on models of synaptic transmission that incorporate unrealistic simplifying assumptions or have too many free parameters. As a result, these techniques have sometimes produced counterintuitive or contradictory results. In contrast, the variance-mean (V-M) technique requires fewer...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Neuroscience Methods
DOI: 10.1016/j.jneumeth.2003.09.019


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