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The anti-oxidant Tempol reverses and partially prevents adrenocorticotrophic hormone-induced hypertension in the rat

Zhang, Yi; Jang, Ryan; Mori, Trevor A; Croft, Kevin D; Schyvens, Chris; McKenzie, Katja; Whitworth, Judith


Objective: To investigate the effects of the antioxidant Tempol on prevention and reversal of adrenocorticotrophic hormone (ACTH)-induced hypertension in the rat, a model of hypertension characterized by nitric oxide deficiency. Methods: Male Sprague-Dawley rats (n = 10 in each group) were treated with either saline or ACTH (0.2 mg/kg per day, s.c.) for 12 days. Tempol (1 mmol/l in drinking water) treatment was started on either day 8 (T8) of ACTH or saline treatment (reversal study), or 4 days...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: Journal of Hypertension
DOI: 10.1097/00004872-200308000-00015


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