Conservation of chromosome arrangement and position of the X in mammalian sperm suggests functional significance
Greaves, Ian; Rens, Willem; Ferguson-Smith, Malcolm A; Griffin, Darren; Graves, Jennifer
We used chromosome painting to show directly that chromosomes occupy fixed positions in the nuclei of mammal but not chicken sperm. We found that the positions of homologous chromosomes are conserved in sperm of two marsupial species that diverged 50-60 million years ago. We also discovered that the X chromosome lies in the region that makes first contact with the egg in marsupial and monotreme mammals, as well as eutherians, and suggest that this position may be related to its propensity for...[Show more]
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