Comparative and functional analyses of LYL1 loci establish marsupial sequences as a model for phylogenetic footprinting
Chapman, Michael A; Charchar, F; Kinston, Sarah; Bird, Catherina; Grafham, Darren; Rogers, Jane; Gruetzner, Frank; Graves, Jennifer; Green, Anne J; Gottgens, Berthold
Comparative genomic sequence analysis is a powerful technique for identifying regulatory regions in genomic DNA. However, its utility largely depends on the evolutionary distances between the species involved. Here we describe the screening of a genomic BAC library from the stripe-faced dunnart, Sminthopsis macroura, formerly known as the narrow-footed marsupial mouse. We isolated a clone containing the LYL1 locus, completely sequenced the 60.6-kb insert, and compared it with orthologous human...[Show more]
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