Complex events in the evolution of the human pseudoautosomal region 2 (PAR2)
Charchar, Fadi J; Svartman, Marta; El-Mogharbel, Nisrine; Ventura, Mario; Kirby, Patrick J; Matarazzo, Maria R; Ciccodicola, A; Rocchi, Mariano; D'Esposito, Maurizio; Graves, Jennifer
The 320-kb human pseudoautosomal region 2 (PAR2) at the tips of the long arms of the X and Y chromosomes is thought to have been duplicated onto the Y chromosome recently in primate evolution. The four genes within PAR2 have been proposed to constitute two zones with different base ratios and transcription, one of which was added recently to the X chromosome. To test this hypothesis, we cloned and mapped PAR2 genes in other species, the lemur, the cat, and a marsupial, the tammar wallaby. None...[Show more]
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