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Pericentric heterochromatin becomes enriched with H2A.Z during early mammalian development

Rangasamy, Danny; Berven, Leise; Ridgway, Patricia; Tremethick, David


Determining how chromatin is remodelled during early development, when totipotent cells begin to differentiate into specific cell types, is essential to understand how epigenetic states are established. An important mechanism by which chromatin can be remodelled is the replacement of major histones with specific histone variants. During early mammalian development H2A.Z plays an essential, but unknown, function(s). We show here that undifferentiated mouse cells of the inner cell mass lack...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: EMBO Journal, The
DOI: 10.1093/emboj/cdg160


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