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The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with alzheimers disease

Selley, M; Close, D R; Stern, Steven


There is evidence that increased blood concentrations of homocysteine may be a risk factor for Alzheimer's disease. (E)-4-hydroxy-2-nonenal (HNE) is a neurotoxic product of lipid peroxidation that is increased in the ventricular fluid and brains of patients with Alzheimer's disease. We measured the concentrations of homocysteine, HNE, vitamin B12 and folate in the plasma of 27 patients with Alzheimer's disease and 25 control subjects. There was a statistically significant increase in the plasma...[Show more]

CollectionsANU Research Publications
Date published: 2002
Type: Journal article
Source: Neurobiology of Aging
DOI: 10.1016/S0197-4580(01)00327-X


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