Combined high-resolution genotyping and geospatial analysis reveals modes of endemic urban typhoid fever transmission
Baker, Stephen; Holt, Kathryn E; Clements, Archie; Karkey, Abhilasha; Arjyal, Amit; Boni, Maciej F; Dongol, Sabina; Hammond, Naomi; Koirala, Samir; Thanh Duy, Pham; Vu Thieu Nga, Tran; Campbell, James I; Dolecek, Christiane; Basnyat, Buddha; Dougan, Gordon; Farrar, Jeremy
Typhoid is a systemic infection caused by Salmonella Typhi and Salmonella Paratyphi A, human-restricted bacteria that are transmitted faeco-orally. Salmonella Typhi and S. Paratyphi A are clonal, and their limited genetic diversity has precluded the identification of long-term transmission networks in areas with a high disease burden. To improve our understanding of typhoid transmission we have taken a novel approach, performing a longitudinal spatial case-control study for typhoid in Nepal,...[Show more]
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