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Early loss of pericytes and perivascular stromal cell-induced scar formation after stroke

Fernandez-Klett, Francisco; Potas, Jason; Hilpert, Diana; Blazej, Katja; Radke, Josefine; Huck, Jojanneke; Engel, Odilo; Stenzel, Werner; Genove, Guillem; Priller, Josef

Description

Despite its limited regenerative capacity, the central nervous system (CNS) shares more repair mechanisms with peripheral tissues than previously recognized. Scar formation is a ubiquitous healing mechanism aimed at patching tissue defects via the generation of fibrous extracellular matrix (ECM). This process, orchestrated by stromal cells, can unfavorably affect the capacity of tissues to restore function. Vascular mural cells have been found to contribute to scarring after spinal cord injury....[Show more]

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/74303
Source: Journal of Cerebral Blood Flow and Metabolism
DOI: 10.1038/jcbfm.2012.187

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