A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial
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Gray, Darren; Li, Yuesheng; Williams, Gail; Zhao, Zheng Yuan; Harn, Donald; Li, Sheng-Ming; Ren, Mao-Yuan; Feng, Zeng; Guo, Feng-Ying; Guo, Jiagang; Zhou, Jie; Dong, Yu-Lan; Li, Yuan; Ross, Allen G.; McManus, Donald P.
Description
Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result...[Show more]
dc.contributor.author | Gray, Darren | |
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dc.contributor.author | Li, Yuesheng | |
dc.contributor.author | Williams, Gail | |
dc.contributor.author | Zhao, Zheng Yuan | |
dc.contributor.author | Harn, Donald | |
dc.contributor.author | Li, Sheng-Ming | |
dc.contributor.author | Ren, Mao-Yuan | |
dc.contributor.author | Feng, Zeng | |
dc.contributor.author | Guo, Feng-Ying | |
dc.contributor.author | Guo, Jiagang | |
dc.contributor.author | Zhou, Jie | |
dc.contributor.author | Dong, Yu-Lan | |
dc.contributor.author | Li, Yuan | |
dc.contributor.author | Ross, Allen G. | |
dc.contributor.author | McManus, Donald P. | |
dc.date.accessioned | 2015-12-13T22:28:36Z | |
dc.identifier.issn | 0020-7519 | |
dc.identifier.uri | http://hdl.handle.net/1885/74274 | |
dc.description.abstract | Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine. | |
dc.publisher | Elsevier | |
dc.source | International Journal for Parasitology | |
dc.title | A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial | |
dc.type | Journal article | |
local.description.notes | Imported from ARIES | |
local.identifier.citationvolume | 44 | |
dc.date.issued | 2014 | |
local.identifier.absfor | 110803 - Medical Parasitology | |
local.identifier.ariespublication | U3488905xPUB4041 | |
local.type.status | Published Version | |
local.contributor.affiliation | Gray, Darren, College of Medicine, Biology and Environment, ANU | |
local.contributor.affiliation | Li, Yuesheng, Queensland Institute of Medical Research | |
local.contributor.affiliation | Williams, Gail, University of Queensland | |
local.contributor.affiliation | Zhao, Zheng Yuan, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Harn, Donald, University of Georgia | |
local.contributor.affiliation | Li, Sheng-Ming, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Ren, Mao-Yuan, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Feng, Zeng, Chinese Centre for Disease Control and Prevention | |
local.contributor.affiliation | Guo, Feng-Ying, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Guo, Jia-Gang, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Zhou, Jie, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Dong, Yu-Lan, Hunan Institute of Parasitic Diseases | |
local.contributor.affiliation | Li, Yuan, Central South University | |
local.contributor.affiliation | Ross, Allen G, Griffith University | |
local.contributor.affiliation | McManus, Donald P, Queensland Institute of Medical Research | |
local.description.embargo | 2037-12-31 | |
local.bibliographicCitation.issue | 9 | |
local.bibliographicCitation.startpage | 659 | |
local.bibliographicCitation.lastpage | 668 | |
local.identifier.doi | 10.1016/j.ijpara.2014.05.005 | |
dc.date.updated | 2015-12-11T08:40:00Z | |
local.identifier.scopusID | 2-s2.0-84904998858 | |
Collections | ANU Research Publications |
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