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A multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial

Gray, Darren; Li, Yuesheng; Williams, Gail; Zhao, Zheng Yuan; Harn, Donald; Li, Sheng-Ming; Ren, Mao-Yuan; Feng, Zeng; Guo, Feng-Ying; Guo, Jiagang; Zhou, Jie; Dong, Yu-Lan; Li, Yuan; Ross, Allen G.; McManus, Donald P.

Description

Despite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result...[Show more]

dc.contributor.authorGray, Darren
dc.contributor.authorLi, Yuesheng
dc.contributor.authorWilliams, Gail
dc.contributor.authorZhao, Zheng Yuan
dc.contributor.authorHarn, Donald
dc.contributor.authorLi, Sheng-Ming
dc.contributor.authorRen, Mao-Yuan
dc.contributor.authorFeng, Zeng
dc.contributor.authorGuo, Feng-Ying
dc.contributor.authorGuo, Jiagang
dc.contributor.authorZhou, Jie
dc.contributor.authorDong, Yu-Lan
dc.contributor.authorLi, Yuan
dc.contributor.authorRoss, Allen G.
dc.contributor.authorMcManus, Donald P.
dc.date.accessioned2015-12-13T22:28:36Z
dc.identifier.issn0020-7519
dc.identifier.urihttp://hdl.handle.net/1885/74274
dc.description.abstractDespite major successes in its control over the past 50. years, schistosomiasis japonica continues to be a public health problem in the People's Republic of China (P.R. China). Historically, the major endemic foci occur in the lakes and marshlands along the Yangtze River, areas where transmission interruption has proven difficult. The current endemic situation may alter due to the closure of the Three Gorges Dam. Considerable environmental and ecological changes are anticipated that may result in new habitats for the oncomelanid intermediate snail host of Schistosoma japonicum (Sj), thereby increasing the risk of transmission. The current national control program for P.R. China involves a multi-component integrated strategy but, despite targeting multiple transmission pathways, certain challenges remain. As the Chinese government pushes towards elimination, there is a requirement for additional tools, such as vaccination, for long-term prevention. Whereas the zoonotic nature of schistosomiasis japonica adds to the complexity of control, it provides a unique opportunity to develop a transmission blocking vaccine targeting bovines to assist in the prevention of human infection and disease. Mathematical modelling has shown that control options targeting the various transmission pathways of schistosomiasis japonica and incorporating bovine vaccination, mass human chemotherapy and mollusciciding could lead to its elimination from P.R. China. Here we present the study design and baseline results of a four-year cluster randomised intervention trial we are undertaking around the schistosomiasis-endemic Dongting Lake in Hunan Province aimed at determining the impact on schistosome transmission of the multi-component integrated control strategy, including bovine vaccination using a heterologous "prime-boost" delivery platform based on the previously tested SjCTPI vaccine.
dc.publisherElsevier
dc.sourceInternational Journal for Parasitology
dc.titleA multi-component integrated approach for the elimination of schistosomiasis in the People's Republic of China: Design and baseline results of a 4-year cluster-randomised intervention trial
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume44
dc.date.issued2014
local.identifier.absfor110803 - Medical Parasitology
local.identifier.ariespublicationU3488905xPUB4041
local.type.statusPublished Version
local.contributor.affiliationGray, Darren, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLi, Yuesheng, Queensland Institute of Medical Research
local.contributor.affiliationWilliams, Gail, University of Queensland
local.contributor.affiliationZhao, Zheng Yuan, Hunan Institute of Parasitic Diseases
local.contributor.affiliationHarn, Donald, University of Georgia
local.contributor.affiliationLi, Sheng-Ming, Hunan Institute of Parasitic Diseases
local.contributor.affiliationRen, Mao-Yuan, Hunan Institute of Parasitic Diseases
local.contributor.affiliationFeng, Zeng, Chinese Centre for Disease Control and Prevention
local.contributor.affiliationGuo, Feng-Ying, Hunan Institute of Parasitic Diseases
local.contributor.affiliationGuo, Jia-Gang, Hunan Institute of Parasitic Diseases
local.contributor.affiliationZhou, Jie, Hunan Institute of Parasitic Diseases
local.contributor.affiliationDong, Yu-Lan, Hunan Institute of Parasitic Diseases
local.contributor.affiliationLi, Yuan, Central South University
local.contributor.affiliationRoss, Allen G, Griffith University
local.contributor.affiliationMcManus, Donald P, Queensland Institute of Medical Research
local.description.embargo2037-12-31
local.bibliographicCitation.issue9
local.bibliographicCitation.startpage659
local.bibliographicCitation.lastpage668
local.identifier.doi10.1016/j.ijpara.2014.05.005
dc.date.updated2015-12-11T08:40:00Z
local.identifier.scopusID2-s2.0-84904998858
CollectionsANU Research Publications

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