Mechanistic insight from activation parameters for the reaction between co-enzyme B 12 and cyanide: further evidence that heterolytic Co�C bond cleavage is solvent-assisted.

Abstract

The potential involvement of the solvent in heterolytic Co-C bond cleavage for vitamin B12 derivatives has been probed by measuring for the first time activation parameters for heterolytic Co-C bond cleavage. If a water molecule is part of the transition