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Prodromal symptoms and early detection of Parkinson's disease in general practice: A nested case-control study

Plouvier, Annette; Hameleers, Renier; van den Heuvel, Eva A J; Bor, Hans; Hartman, Tim C. olde; Bloem, Bastiaan; Lagro-Janssen, Antoine L; van Weel, Chris

Description

Background: Timely diagnosis of Parkinson's disease (PD), facilitating early intervention, depends largely on the GP's awareness of early symptomatology. For general practice, it is unknown which prodromal symptoms (symptoms preceding the typical motor symptoms of PD) demand the GP's alertness. Objective: To assess prodromal symptoms that should alert the GP to the possibility of PD in primary care patients. Methods: A nested case-control study was carried out in a population of approximately...[Show more]

dc.contributor.authorPlouvier, Annette
dc.contributor.authorHameleers, Renier
dc.contributor.authorvan den Heuvel, Eva A J
dc.contributor.authorBor, Hans
dc.contributor.authorHartman, Tim C. olde
dc.contributor.authorBloem, Bastiaan
dc.contributor.authorLagro-Janssen, Antoine L
dc.contributor.authorvan Weel, Chris
dc.date.accessioned2015-12-13T22:28:28Z
dc.identifier.issn0263-2136
dc.identifier.urihttp://hdl.handle.net/1885/74222
dc.description.abstractBackground: Timely diagnosis of Parkinson's disease (PD), facilitating early intervention, depends largely on the GP's awareness of early symptomatology. For general practice, it is unknown which prodromal symptoms (symptoms preceding the typical motor symptoms of PD) demand the GP's alertness. Objective: To assess prodromal symptoms that should alert the GP to the possibility of PD in primary care patients. Methods: A nested case-control study was carried out in a population of approximately 12 000 patients registered in the Continuous Morbidity Registration database affiliated with the University of Nijmegen in the Netherlands. The database pools subject data from four primary care practices. The subjects comprised all 86 patients diagnosed with PD between 1972 and 2007, and 78 controls, matched by sex, age, socioeconomic status and primary care practice. The primary measures of outcome were the prodromal symptoms presenting in the two years prior to the diagnosis of PD. The number (and type) of referrals and diagnostic tests were also assessed. Results: In the two-year period prior to diagnosis, PD patients more often presented with functional somatic symptoms, constipation, hyperhidrosis and sleep disorders than controls. Patients also more frequently experienced more than one prodromal symptom and were more often referred within the primary care team or to a medical specialist. Conclusions: Prodromal symptoms of PD are encountered in general practice. GPs should be alert when patients present with multiple prodromal symptoms in a two-year period, especially considering the benefits of early intervention, and the future possibilities for disease-modifying therapy.
dc.publisherOxford University Press
dc.sourceFamily Practice
dc.titleProdromal symptoms and early detection of Parkinson's disease in general practice: A nested case-control study
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume31
dc.date.issued2014
local.identifier.absfor111700 - PUBLIC HEALTH AND HEALTH SERVICES
local.identifier.ariespublicationU3488905xPUB4017
local.type.statusPublished Version
local.contributor.affiliationPlouvier, Annette, Radbound University Medical Center
local.contributor.affiliationHameleers, Renier, Radbound University Medical Center
local.contributor.affiliationvan den Heuvel, Eva A J, Radbound University Medical Center
local.contributor.affiliationBor, Hans , Radboud University Nijmegen Medical Center
local.contributor.affiliationHartman, Tim C. olde, Radboud University Nijmegen Medical Centre
local.contributor.affiliationBloem, Bastiaan, Radbound University Medical Center
local.contributor.affiliationVan Weel, Chris, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationLagro-Janssen, Antoine L, Radboud University Nijmegen Medical Centre
local.description.embargo2037-12-31
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage373
local.bibliographicCitation.lastpage378
local.identifier.doi10.1093/fampra/cmu025
local.identifier.absseo920112 - Neurodegenerative Disorders Related to Ageing
dc.date.updated2015-12-11T08:38:51Z
local.identifier.scopusID2-s2.0-84904718223
local.identifier.thomsonID000340070500002
CollectionsANU Research Publications

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