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Binding of fullerenes and nanotubes to MscL

Hilder, Tamsyn; Ridone, Pietro; Nakayama, Yoshitaka; Martinac, Boris; Chung, Shin-Ho


Multi-drug resistance is becoming an increasing problem in the treatment of bacterial infections and diseases. The mechanosensitive channel of large conductance (MscL) is highly conserved among prokaryotes. Evidence suggests that a pharmacological agent that can affect the gating of, or block the current through, MscL has significant potential as a new class of antimicrobial compound capable of targeting a range of pathogenic bacteria with minimal side-effects to infected patients. Using...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Scientific Reports
DOI: 10.1038/srep05609
Access Rights: Open Access


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