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Fungal Polyketide Synthase Product Chain-Length Control by Partnering Thiohydrolase

Zabala, Angelica O.; Chooi, Yit-Heng; Choi, Moon Seok; Lin, Hsiao-Ching; Tang, Yi


Fungal highly reducing polyketide synthases (HRPKSs) are an enigmatic group of multidomain enzymes that catalyze the biosynthesis of structurally diverse compounds. This variety stems from their intrinsic programming rules, which permutate the use of tailoring domains and determine the overall number of iterative cycles. From genome sequencing and mining of the producing strain Eupenicillium brefeldianum ATCC 58665, we identified an HRPKS involved in the biosynthesis of an important protein...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: ACS chemical biology
DOI: 10.1021/cb500284t


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