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Chromatinized protein kinase C-Θ directly regulates inducible genes in epithelial to mesenchymal transition and breast cancer stem cells

Zafar, Anjum; Wu, Fan; Hardy, Kristine; Li, Jasmine; Tu, Wen Juan; McCuaig, Robert; Harris, Janelle; Khanna, Kum; Attema, Joanna; Gregory, Philip A; Goodall, Gregory; Harrington, Kirsti; Dahlstrom, Jane; Boulding, Tara; Madden, Rebecca; Tan, Abel; Milburn, Peter J; Rao, Sudha


Epithelial to mesenchymal transition (EMT) is activated during cancer invasion and metastasis, enriches for cancer stem cells (CSCs), and contributes to therapeutic resistance and disease recurrence. Signal transduction kinases play a pivotal role as chromatin- anchored proteins in eukaryotes. Here we report for the first time that protein kinase C-theta (PKC-θ) promotes EMT by acting as a critical chromatin-anchored switch for inducible genes via transforming growth factor β (TGF-β) and the...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Molecular and Cellular Biology
DOI: 10.1128/MCB.01693-13
Access Rights: Open Access


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