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Spleen stroma maintains progenitors and supports long-term hematopoiesis

O'Neill, Helen; Griffiths, Kristin; Periasamy, Pravin; Hinton, Rebecca; Petvises, Sawang; Hey, Ying Ying; Tan, Jonathan


Hematopoietic stem/progenitor cells (HSPC) differentiate in the context of stromal niches producing cells of multiple lineages. Limited success has been achieved in the past with induction of hematopoiesis in vitro. Previously, spleen long-term stromal cultures (LTC) were shown to continuously support restricted hematopoiesis for production of novel dendritic-like cells (LTC-DC). An in vivo equivalent dendritic cell type was then described which is specific for spleen. The in vivo counterpart...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Current Stem Cell Research & Therapy
DOI: 10.2174/1574888X09666140421115836


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