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Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity

de Villiers, Marianne; Macuamule, Cristiano; Spry, Christina; Hyun, Yoo-Min; Strauss, Erick; Saliba, Kevin

Description

Pantothenamides are secondary or tertiary amides of pantothenic acid, the vitamin precursor of the essential cofactor and universal acyl carrier coenzyme A. A recent study has demonstrated that pantothenamides inhibit the growth of blood-stage Plasmodium

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
URI: http://hdl.handle.net/1885/74062
Source: ACS Medicinal Chemistry Letters
DOI: 10.1021/ml400180d

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