3D Electrospun scaffolds promote a cytotrophic phenotype of cultured primary astrocytes
Lau, Chew L; Kovacevic, Michelle; Tingleff, Tine S; Forsythe, John S.; Cate, Holly S; Merlo, Daniel; Cederfur, Cecilia; Maclean, Francesca; Parish, Clare L.; Horne, Malcolm K.; Nisbet, David; Beart, Philip M
Astrocytes are a target for regenerative neurobiology because in brain injury their phenotype arbitrates brain integrity, neuronal death and subsequent repair and reconstruction. We explored the ability of 3D scaffolds to direct astrocytes into phenotypes with the potential to support neuronal survival. Poly-ε-caprolactone scaffolds were electrospun with random and aligned fibre orientations on which murine astrocytes were sub-cultured and analysed at 4 and 12 DIV. Astrocytes survived,...[Show more]
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|Source:||Journal of Neurochemistry|
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