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Optimizing microarray in experimental hypertension

Shannon, M Frances; McKenzie, Katja; Edgley, Amanda; Rao, Sudha; Peng, Kaimen; Shweta, Amany; Schyvens, Chris; Anderson, Warwick P; Wilson, Susan; Pittelkow, Yvonne; Ohms, Stephen J; Whitworth, Judith

Description

Background. Genetic noise between outbred animals can potentially be a major confounder in the use of microarray technology for gene expression profiling. The study of paired organs from the same animal offers an alternative approach (e.g., for studies of the kidney in experimental hypertension). The present study was undertaken to determine the level of genetic noise between outbred adult Sprague-Dawley (SD) rats, and to determine the effects of unilateral nephrectomy on changes in gene...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
URI: http://hdl.handle.net/1885/73966
Source: Kidney International
DOI: 10.1111/j.1523-1755.2005.00090.x

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