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Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9

Blink, Elizabeth; Zhou, Jiansheng; Hu, Wei; Calanni, Sophina; Trapani, Joseph A; Bird, Phillip I; Jans, David A


Conditional on perforin-dependent delivery to the nucleus of target cells, the cytolytic granule serine protease granzyme B (GrB) plays a central role in eliciting the nuclear events of apoptosis, as shown by the fact that reducing GrB nuclear entry prevents nuclear apoptosis. Apart from a requirement for cytosolic factors and lack of dependence on the guanine-nucleotide-binding protein Ran, little is known regarding the nuclear import pathway of GrB. In this study we use quantitative yeast...[Show more]

CollectionsANU Research Publications
Date published: 2005
Type: Journal article
Source: Journal of Celluar Biochemistry
DOI: 10.1002/jcb.20415


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