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A Role For Intrathymic B Cells in the Generation of Natural Regulatory T Cells

Walters, Stacey N; Webster, Kylie E; Daley, Stephen; Grey, Shane T


B cells inhabit the normal human thymus, suggesting a role in T cell selection. In this study, we report that B cells can modulate thymic production of CD4+ Foxp3+ T cells (regulatory T cells [Tregs]). Mice with transgenic expression of BAFF (BAFF-Tg) harbor increased numbers of Helios+Foxp3+ thymic Tregs and, similar to some human autoimmune conditions, also exhibit increased numbers of B cells colonizing the thymus. Distinct intrathymic B cell subpopulations were identified, namely B220+,...[Show more]

CollectionsANU Research Publications
Date published: 2014
Type: Journal article
Source: Journal of Immunology
DOI: 10.4049/jimmunol.1302519


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